Binding of amyloid β peptide to β 2 adrenergic receptor induces PKA‐dependent AMPA receptor hyperactivity
نویسندگان
چکیده
منابع مشابه
Binding of amyloid peptide to 2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity
Progressive decrease in neuronal function is an established feature of Alzheimer’s disease (AD). Previous studies have shown that amyloid (A ) peptide induces acute increase in spontaneous synaptic activity accompanied by neurotoxicity, and A induces excitotoxic neuronal death by increasing calcium influx mediated by hyperactive -amino-3-hydroxy-5-methyl-4isoxazole propionate (AMPA) receptors. ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.10-156661